Too Much Niacin And Heart Harm?

Niacin, also known as vitamin B3, is widely used for its cholesterol-lowering effects and its role in heart health. However, concerns have arisen due to the potential side effects and risks associated with high doses of niacin. Recent research links excessive niacin intake to heart issues. A study in Nature Medicine explored these matters in depth, revealing that high levels of niacin raise the risk of heart attack, stroke, and other cardiovascular diseases. The study, funded by the National Heart, Lung, and Blood Institute, analyzed blood samples from cardiac patients. Researchers found that 4PY, produced when there is too much niacin, was present in some samples. They further examined 2PY. Follow-up studies evaluated data from 3,163 people with heart disease or CVD signs. These studies showed that those with 4PY and 2PY in their blood had a greater chance of experiencing negative cardiac events. Injecting mice with 4PY and 2PY revealed inflammation in their blood vessels, indicating CVD risk. The study authors concluded that these breakdown products of excess niacin are associated with residual CVD risk and suggest an inflammation-dependent mechanism. About a quarter of Americans have higher niacin levels than recommended. The National Heart, Lung, and Blood Institute notes that U.S. niacin consumption averaged more than triple the Recommended Daily Allowance from 2017 to 20. Hazen, a senior study author, says an excess amount is a concern. Niacin is essential but taking too much can lead to serious health complications. Common side effects include flushing, itching, nausea, and headaches, which can be mitigated by starting with a lower dose. High doses should be under the guidance of a healthcare professional. Symptoms of an overdose include severe flushing, dizziness, rapid heartbeat, abdominal pain, and liver damage. Avoid taking too much and seek medical advice if experiencing these symptoms. The recommended daily allowance for niacin is around 14-16 mg for adults and up to 18 mg for pregnant women. Therapeutic doses for cholesterol management can be higher, but doses above 500 mg per day pose health risks. The study emphasizes adhering to recommended dosages and consulting a healthcare provider for larger doses.